Gliomas harboring mutations in Isocitrate-Dehydrogenase (IDH) 1/2 exhibits a neomorphic-activity resulting in production of 2-hydroxyglutarate (2HG) by 2-3 orders of magnitude. Non-invasive detection of 2HG using conventional 1H Magnetic Resonance Spectroscopy (MRS) is challenging due to extensive overlap with the resonances of neighboring metabolites. Here we have designed a TE-Averaged PRESS 1H-MRS that reduces the spectral-overlaps of GABA, Gln, Glu and glutathione signals on 2HG-2.25ppm-resonance that provides a reliable-detection of 2HG. We have also estimated T2 in each brain-tumor by taking the advantage of multiple-TEs used in TE-averaging acquisitions, and used patient-specific T2 for estimation of 2HG.
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