In the treatment of pediatric medulloblastomas, cranial radiation therapy (CRT) may induce long-term effects including CRT-induced vascular injury and cognitive impairments. 7T Susceptibility-weighted MRI was used to characterize CRT-induced injury in the form of cerebral microbleeds (CMBs) as potential markers of cognitive deficits. The majority of CMBs were located in the frontal lobe, which develop late in the adolescent brain. CMB density was associated with deficits in working and visual memory as a function of time since CRT. This work supports a modification of future standards for defining radiation target volumes, with evidence for early intervention with cognitive rehabilitation strategies.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords