Cerebral arteriolar vasomotor function would be a biomarker for early diagnosis of dementia. We developed a quantitative mapping technique for cerebral arteriolar vasomotor function without administrating any agents. The natural respiratory fluctuation of CO2 in arterial blood was used, which alters cerebral blood flow and venous blood oxygenation, and hence modulates the MRI signal. This new technique is based on our finding of a strong correlation in MR signals between the cardiac fluctuation in brain parenchyma and the respiratory fluctuation at the sagittal sinus. Using this new mapping technique, the degeneration of arteriolar vasomotor function associated with aging was observed.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords