Meeting Banner
Abstract #4257

Quantitative cerebral arteriolar vasomotor function mapping by spectral analysis of time series MR signal fluctuations

Minghui Tang1, Keigo Nishi2, and Toru Yamamoto1

1Faculty of Health Sciences, Hokkaido University, Sapporo, Japan, 2Department of Radiology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan

Cerebral arteriolar vasomotor function would be a biomarker for early diagnosis of dementia. We developed a quantitative mapping technique for cerebral arteriolar vasomotor function without administrating any agents. The natural respiratory fluctuation of CO2 in arterial blood was used, which alters cerebral blood flow and venous blood oxygenation, and hence modulates the MRI signal. This new technique is based on our finding of a strong correlation in MR signals between the cardiac fluctuation in brain parenchyma and the respiratory fluctuation at the sagittal sinus. Using this new mapping technique, the degeneration of arteriolar vasomotor function associated with aging was observed.

This abstract and the presentation materials are available to members only; a login is required.

Join Here