Meeting Banner
Abstract #4258

Cardiovascular risk factors, cerebral blood flow, and cognitive functions: preliminary results in a community based study in Chinese elders

Xin Hong1, Sei Hwan Oh1, Ying Hwey Nai1, Saima Hilal2,3, Suz-Chieh Sung1, Mohammad Kamran Ikram3,4, Christopher Chen2,3, and Kai-Hsiang Chuang1

1Singpare Bioimaging Consortium, Agency for Science Technology and Research, Singapore, Singapore, 2Department of Pharmacology, National University of Singapore, 3Memory Aging & Cognition Centre, National University of Singapore, 4Singapore Eye Research Institute, Singapore National Eye Center

Cerebral blood flow (CBF) is an important biomarker of the brain function and has been shown to correlate with cognitive performance in diseases. Since cardiovascular and metabolic complications are common in elders, to understand the influence of vascular confound in cognitive correlation, we investigated how cardiovascular risk factors may affect the relationship between cognitive functions and CBF in non-demented elders. We found that mean arterial blood pressure, haematocrit, blood cholesterol and glucose levels had significant negative effects on CBF. This suggests that cardiovascular risk factors shall be taken into consideration when analyzing CBF in aging, cognitive impairment, and neurodegenerative diseases.

This abstract and the presentation materials are available to members only; a login is required.

Join Here