Cerebral blood flow (CBF) is an important biomarker of the brain function and has been shown to correlate with cognitive performance in diseases. Since cardiovascular and metabolic complications are common in elders, to understand the influence of vascular confound in cognitive correlation, we investigated how cardiovascular risk factors may affect the relationship between cognitive functions and CBF in non-demented elders. We found that mean arterial blood pressure, haematocrit, blood cholesterol and glucose levels had significant negative effects on CBF. This suggests that cardiovascular risk factors shall be taken into consideration when analyzing CBF in aging, cognitive impairment, and neurodegenerative diseases.
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