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Abstract #4259

Oscillating Gradient Spin Echo Diffusion Tensor MRI of the Corpus Callosum with Typical Aging

Pascal Tétreault1, Diana Valdés Cabrera1, Robert Stobbe1, Corey Baron1, and Christian Beaulieu1

1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada

This study compared short diffusion time (4 ms) oscillating gradient spin echo (OGSE) relative to regular long diffusion time (40 ms) pulsed gradient spin echo (PGSE) DTI in healthy individuals over a 40 year age span (n=12, 24 to 67 years old) to identify unique microstructure organization and reveal potential age related changes in three portions of the corpus callosum. Diffusivity and anisotropy were shown to depend on the diffusion time, mostly in the splenium, and these changed with age possibly reflecting alterations of restrictive dimensions such as the loss of specific axon diameters with aging.

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