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Abstract #4261

MR R2* and Quantitative Susceptibility Mapping: Variability in Normal Subjects across the Adult Lifespan

Christopher M O'Neill1,2, Cheryl R McCreary1,2, and Richard Frayne1,2

1Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 2Seaman Family MR Research Centre, Foothills Medical Centre, Alberta Health Serivces, Calgary, AB, Canada

R2* relaxation and susceptibility measurements are both candidate biomarkers for studying brain change. The relative variability of R2* and quantitative susceptibility mapping (QSM) approaches was studied in six deep brain regions in 182 normal subjects (18-89 years). The variability of R2* measures (average coefficient of variation, CoV: 0.33, mean ± standard deviation over regions) was found to be significantly less than QSM measurements (average CoV: 5.72). The variability in R2* measurements was found to vary with age, unlike QSM which showed no age effects. The increased variability observed in QSM measurements, however, may obscure smaller age effects.

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