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Abstract #4262

The Effects of Long-Term Physical Intervention for Active Ageing on the White Matter Hyperintensities in Older Adults

Toshiharu Nakai1,2, Noriko Ogama3, Takashi Sakurai4, Mika Ueno1, Sachiko Kiyama1,5, and Ayuko Tanaka1,6

1NeuroImaging & Informatics, National Center for Geriatrics & Gerontology, Ohbu, Japan, 2Department of Radiological Science, Nagoya University Graduate School of Medicine, Nagoya, Japan, 3Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Ohbu, Japan, 4Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics & Gerontology, Ohbu, Japan, 5College of Liberal Arts and Sciences, Mie University, Tsu, Japan, 6Faculty of Human Sciences, Kobe Shoin Women's University, Kobe, Japan

The relationship between the history of participation in community based physical exercise activity and the volume of white matter hyperintensity was evaluated in order to investigate the long-term effects of physical exercises on the neurophysiological status of brain to support cognitive processing in older adults. The FLAIR MR images obtained from 54 community dwelling older adults were segmented semi-automatically and the WMH volumes were quantified. It was suggested that long-term physical exercises more than 5 years for 90 minutes once per week may potentially reduce the progress of WMH lesions as well as the risk of fall.

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