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Abstract #4264

Changes in myelination and cortical thickness with advancing age

Andrew John Carradus1, Benjamin Hunt1, Prejaas Tewarie1, Nicolas Geades1, Simon Shah1, Olivier Mougin1, Matthew Brookes1, and Penny Gowland1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

This study explores the relationships that cortical myelination and cortical thickness have with age, and expands on existing literature by investigating whether the previously reported trends are still present when only looking at individual lobes of the brain. We find that quadratic variations occur in all four lobes of the brain in regards to myelination, and that cortical thickness declines linearly with age in all lobes except the temporal. We also find that myelination levels and cortical thickness appear to change independently of each other.

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