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Abstract #4265

Cross-Sectional Assessment of Diffusion Parameters in Specific Brain Tracts correlated with Cortical Thinning throughout Healthy Aging

Maíra Siqueira Pinto1, Antônio Carlos dos Santos2, and Carlos Ernesto Garrido Salmon1

1InBrain Lab, Department of Physics, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil, 2Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

The human brain is a complex structure that undergoes continuous, non-linear changes over the lifespan. We used anatomic and diffusion data from 165 healthy subjects, collected retrospectively from CCIFM/HC-FMRP. T1-weighted images were used for cortical parcellation, thus 102 of 148 cortical regions had statistically significant decrease with age. Three fiber tracts were selected: Corpus Callosum, Uncinate Faciculus and Corticospinal Tract, their diffusion parameters, FA and MD, showed significant relationship with cortical thickness of the biggest cortical area in the ending of each tract. Despite these correlations, it was possible to verify that age is the pivotal variable in this relationship.

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