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Abstract #4266

Human Connectome Project (HCP) Lifespan Pilot: age-course of structural, microstructural and functional parameters in the hubs of the default mode network

Daniele Mascali1, Emily Kittelson2, Keith Jamison2, Kâmil Uğurbil2, Essa Yacoub2, Shalom Michaeli2, Lynn Eberly3, Melissa Terpstra2, Federico Giove1, and Silvia Mangia2

1Museo Storico della Fisica e Centro Studi e Ricerche “Enrico Fermi”, Rome, Italy, 2Center for Magnetic Resonance Research, Dept. of Radiology, University of Minnesota, Minneapolis, MN, United States, 3Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States

Age-courses of multiple MRI outcomes were here characterized with a specific focus to default mode network (DMN) regions. Data were collected with unprecedented sensitivity and spatial resolution using the Human Connectome Project Lifespan Pilot protocol from 65 subjects divided in 4 age-groups (teen, young, middle-age and older adults). Age-related decreases of grey matter volumes, mean diffusivity, amplitude of resting-state oscillations and regional homogeneity were observed in both anterior and posterior DMN, and were more pronounced in anterior than in posterior DMN. Connectivity between posterior and anterior DMN regions remained relatively stable during the lifespan.

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