Abstract #4267

Investigating the compensatory mechanisms of the ageing brain in response to a sub-maximal exercise task

Andrew Hale^1,2, Penny Gowland¹, Paul Greenhaff^1,2, and Susan Francis¹

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²MRC/ARUK Centre for Musculoskeletal Ageing Research, University of Nottingham, Nottingham, United Kingdom

Age-related alterations in cerebral vascular function may be better understood by investigating cerebral response to exercise. We performed a MR study involving low/moderate intensity exercise in healthy young and older subjects. We assess the effect of exercise on CBF response, cerebral oxygenation, and CMRO₂. We also investigate the relationship of GM-volume and physical fitness with ageing. At rest, there was no difference between CBF and CMRO₂ but an increase in oxygen extraction with age. On exercise the age-related increase in OEF remained, however CBF and CMRO₂ were blunted in older subjects. GM-volume was found to be associated with VO_2max.

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