Abstract #4270

Effects of Working Memory Training on Microstructural Brain Changes in HIV-positive and Seronegative Subjects

Chad Otoshi¹, Thomas Ernst¹, Kenichi Oishi², Hua Jun Liang¹, David Greenstein¹, and Linda Chang¹

¹Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, United States, ²Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, MD, United States

Microstructural brain changes before, 1-month and 6-months and after working Memory Training was evaluated in both HIV-positive and seronegative individuals. While working memory training improved performance in both trained and non-trained working memory tasks, brain diffusivities increased in most brain regions after training in both groups, more in HIV than controls in some regions. These findings suggest ongoing brain inflammation associated with normal aging or HIV may mask the training-related changes in DTI measures.

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