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Abstract #4271

Aging effects on kurtosis measures of limbic and association white matter tracts

Qinmu Peng1,2, King Kevin3,4, Minhui Ouyang1, Hanzhang Lu5, and Hao Huang1,2

1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Imaging, Huntington Medical Research Institutes, 4Department of Radiology, University of Texas Southwestern Medical Center, 5Department of Radiology, Johns Hopkins University

Numerous studies have revealed that DTI-derived metrics are sensitive to the microstructural changes of the aging white matter tracts. However, microstructural changes associated with non-Gaussian water diffusion cannot be quantified by DTI-derived metrics, but uniquely quantified by DKI-derived metrics. Little is known on the progressive white matter microstructural changes measured by DKI-derived metric during aging. In this study, we found that the measurements of DKI-derived mean kurtosis (MK) decrease heterogeneously across white matter tracts, characterized with significant MK decreases in limbic tracts including fornix and cingulum and insignificant MK decreases in the association tracts.

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