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Abstract #4276

Sub-clinical trait anxiety relates to cerebral blood flow in brain regions related to autonomic arousal

William J Cottam1,2,3, Diane Reckziegel1,2,3, Marianne M Drabek1,2,3, and Dorothee P Auer1,2,3

1Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, 2Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, 3Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Arterial spin labelling is a powerful, non-invasive tool to map cerebral blood flow (CBF) in the study of neural activity patterns underpinning spontaneous behaviour or personality traits. In this study we sought to directly investigate the effects of negative affect, specifically trait anxiety on local cerebral blood flow in a group of patients with chronic pain known to have mildly elevated anxiety scores. This study found widespread cerebral blood flow in osteoarthritis subjects with chronic pain that correlate significantly with trait anxiety, overlapping with regions previously reported to relate to autonomic functions. fMRI studies should account for increased physiological arousal.

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