Meeting Banner
Abstract #4275

Anomalous diffusion γ metrics detects physiological and microstructural changes in brain normal aging

Michele Guerreri1,2, Alessandra Caporale1,3, Marco Palombo4, Emiliano Macaluso5, Marco Bozzali6, and Silvia Capuani1

1CNR ISC UOS Sapienza University of Rome, Rome, Italy, Rome, Italy, 2SAIMLAL Dept., Morphogenesis and Tissue Engineering, Sapienza University of Rome, Rome, Italy, 3SAIMLAL Dept., Morphofunctional Sciences, Sapienza University of Rome, 4MIRCen, CEA/DSV/I2BM, Fontenay-Aux Roses, France, 5ImpAct Team, Lyon Neurosince Research Center, Lyon, France, 6Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy

The intent of this study was to test the potential of parameters extracted by the so-called anomalous diffusion (AD) stretched exponential γ-imaging model, to detect microstructural modifications occurring in brain during normal aging. Conventional DTI metrics was also considered. 27 healthy volunteers with age range 21-77y underwent DW acquisitions. Parametric maps of Mean γ (Mγ) and γ Anisotropy (γA) were obtained and a quantitative analysis was carried in different regions of White and Deep Grey Matter. We found that AD and DTI parameters correlations with age indicate changes in different brain regions diversifying thus aging patterns.

This abstract and the presentation materials are available to members only; a login is required.

Join Here