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Abstract #4358

HCC treated with 90Yttrium radioembolization: can pre-treatment and 6week post-treatment volumetric ADC histogram measurements predict subsequent tumor response?

Sonja Gordic1,2, Mathilde Wagner1,3, Riccardo Zanato1, Stefanie Hectors1, Cecilia Besa1, Edward Kim4, and Bachir Taouli1,4

1Translational and Molecular Imaging Institute, New York, NY, United States, 2Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, 3Radiology, Groupe Hospitalier Pitié Salpêtrière, Paris, France, 4Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, Switzerland

We evaluated the potential of volumetric ADC histogram measurements (vADC) obtained pre- and 6 weeks (6w) post-treatment for prediction of HCC response to 90Yttrium radioembolization (RE). 22 patients underwent MRI at baseline and 6w after RE using a routine liver MRI protocol including DWI. Tumor response was assessed by mRECIST at 6 months post treatment. vADC mean, median and mode obtained at 6w post-treatment were significantly different between patients with partial/complete response vs. those with stable/progressive disease, and were a significant predictor of complete tumor response at 6 months, with vADC mode performing best. Pre-treatment vADC did not have any predictive value for response.

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