Abstract #4359

Evaluation of HCC Response to Loco-regional Therapy: Validation of Response Criteria with MRI using Explant as a Reference

Sonja Gordic^1,2, Idoia Corcuera-Solano³, Ashley Stueck⁴, Pamela Argiriadi³, Preethi Guniganti³, Michael King³, Edward Kim³, Swan Thung⁴, and Bachir Taouli^1,3

¹Translational and Molecular Imaging Institute, New York, NY, United States, ²Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, ³Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

We assessed the performance of various imaging response criteria for the prediction of complete pathologic necrosis (CPN) of hepatocellular carcinoma post locoregional therapy on liver explant. Patients who underwent liver transplantation after locoregional therapy were included in this retrospective study. All patients underwent MRI using routine liver protocol within 90 days of liver transplant. RECIST, mRECIST, EASL, percentage of necrosis on subtraction images, and DWI (signal intensity and ADC) were assessed. CPN was retrospectively assessed in all tumors at histopathology. mRECIST, EASL, percentage of necrosis and signal intensity on DWI were all significant predictors of CPN while RECIST and ADC criteria were not.

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