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Abstract #4360

Value of Tumor Stiffness Measured with MR Elastography for Assessment of Response of Hepatocellular Carcinoma to Locoregional Therapy

Sonja Gordic1,2, Jad Bou Ayache3, Paul Kennedy 1, Cecilia Besa1, Mathilde Wagner1, Octavia Bane1, Richard Ehman4, Edward Kim3, and Bachir Taouli1,3

1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, 3Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Department of Radiology, Mayo Clinic, Rochester, MN, United States

We correlated tumor stiffness (TS) measured with MR elastography (MRE) to degree of tumor enhancement and necrosis on contrast-enhanced T1-weighted imaging (CE-T1WI) in hepatocellular carcinomas (HCC) treated with locoregional therapy. Patients with HCC who underwent locoregional treatment and controls with newly diagnosed untreated HCC were included. TS values were obtained by placing regions of interest (ROIs) over HCCs on stiffness maps. Visual assessment of tumor necrosis on subtraction images and calculation of enhancement ratios by placing ROIs over tumors on CE-T1WI was performed. TS measured with MRE showed a significant correlation with tumor enhancement and necrosis.

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