The changes that occur over a cell cycle play a vital role in mediating a cell’s sensitivity towards radiation therapy. Radiation exposure is expected to arrest cells at a particular cell cycle phase which improves the effectiveness of subsequent doses of radiation/chemotherapy. Cells in different phases have different sizes that can be detected by diffusion MRI with appropriate diffusion times. In this study, we evaluate the hypothesis in a rat glioma model that measurements of mean tumor cell size provides a means to quantify changes of cell phase distributions, and hence is capable of monitoring tumor response to radiotherapy.
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