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Abstract #4361

in vivo detection of tumor response to radiotherapy using Imaging Micro-structural Parameters Using Limited Spectrally Edited Diffsuion

xiaoyu jiang1, hua li1, zou yue1, junzhong xu1, and john Gore1

1vanderbilt university institute of imaging science, nashville, TN, United States

The changes that occur over a cell cycle play a vital role in mediating a cell’s sensitivity towards radiation therapy. Radiation exposure is expected to arrest cells at a particular cell cycle phase which improves the effectiveness of subsequent doses of radiation/chemotherapy. Cells in different phases have different sizes that can be detected by diffusion MRI with appropriate diffusion times. In this study, we evaluate the hypothesis in a rat glioma model that measurements of mean tumor cell size provides a means to quantify changes of cell phase distributions, and hence is capable of monitoring tumor response to radiotherapy.

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