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Abstract #4362

ADC and Kurtosis parameters show early response to anti-angiogenic therapy in patients with liver metastases

Mihaela Rata1, Khurum Khan1, David Collins1, Matthew Orton1, James d'Arcy1, Nina Tunariu1, Maria Bali1, Ian Chau1, Nicola Valeri1, David Cunningham1, Martin O Leach1, and Dow-Mu Koh1

1CR-UK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom

Diffusion Weighted Imaging (DWI) is a valuable method of characterising tumour cellularity and assessing tumour response to therapy. Diffusion Kurtosis Imaging (DKI) is now being investigated outside of the brain, as the diffusional kurtosis metrics are strongly linked to cellular microstructure and heterogeneity in tissues. This work assesses tumour response to anti-angiogenic therapies as derived from DWI and DKI data in a cohort of patients with liver metastases enrolled on an early phase clinical trial. Our results demonstrate a significant cohort response to treatment of the ADC parameter, but also observed significant non-Gaussian diffusion behaviour.

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