90% of cancer related deaths are caused by cancer metastasis, a process where cells leave the primary tumour, disseminate and form outgrowth at the secondary metastatic site. The tumour microenvironment provides crucial signals ((bio)chemical, mechanical) to regulate tumour formation, progression, and cell spread throughout the body. Translation of mechanical forces, displacements and deformations into biochemical signals (i.e. mechanotransduction) affects their cell behaviour (adhesion, spread, survival).1,2 We show here that multiple treatment of tumour spheroids (solid tumour model in vitro) with focussed shear waves operating at specific frequency and amplitude results in reduced growth and reduced invasive behaviour of cancer cells.
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