Abstract #4376

Predicting MGMT expression levels in glioma patients using multi-inversion-time PASL

Yuchao Liang¹, Yinyan Wang¹, Tianyi Qian², Josef Pfeuffer³, Shaowu Li⁴, Tao Jiang^1,5, and Lei Wang¹

¹Neurosurgery, Beijing Tiantan Hospital, Beijing, People's Republic of China, ²MR Collaborations NE Asia, Siemens Healthcare, Beijing, People's Republic of China, ³Application Development, Siemens Healthcare, Erlangen, Germany, ⁴Neuroimaging center, Beijing Neurosurgical Insitute, Beijing, People's Republic of China, ⁵Neurosurgery, Beijing Neurosurgical Insitute, Beijing, People's Republic of China

To evaluate the differences in cerebral blood flow between glioma patients with high MGMT expression and those with low MGMT expression, we retrospectively compared cerebral blood flow in pre-operative MR images acquired using multi-inversion-time PASL from glioma patients with histopathologically confirmed high MGMT expression and those with histopathologically confirmed low MGMT expression. The results demonstrate that MGMT expression status significantly correlates with both quantitative CBF and relative CBF.

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