Meeting Banner
Abstract #4377

Utilizing correlations between Ktrans and plasma volume fraction estimates improves extended Kety modelling of DCE-MRI data

Matthew R Orton1, Mihaela Rata1, David J Collins1, James A d'Arcy1, and Martin O Leach1

1CRUK Cancer Imaging Centre, Division of Radiotherapy and Imaging, Institute of Cancer Research, Sutton, United Kingdom

The extended Kety model is widely used for deriving quantitative perfusion and vascularity measures from DCE-MRI. In practice the signal contribution from the plasma space can be low compared to the signal-to-noise ratio (SNR) of the data which leads to cases where Ktrans is non-zero (indicating delivery of contrast to the tissues), but where the plasma volume fraction is estimated as zero: a logical contradiction. This work describes a model and fitting methodology to overcome this that makes use of a relationship between Ktrans and the plasma volume fraction to ensure both are positive or both are zero.

This abstract and the presentation materials are available to members only; a login is required.

Join Here