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Abstract #4380

R2* relaxation affects pharmacokinetic analysis of DCE-MRI at high field strength

Eugene Kim1, Jana Kim1, and Siver Andreas Moestue1

1MR Cancer Group, Department of Circulation and Medical Imaging, NTNU Norwegian University of Science and Technology, Trondheim, Norway

In DCE-MRI, the effect of the r2* relaxivity of gadolinium-based contrast agents is often assumed to be negligible. Here, the validity of this assumption at 7T was tested. DCE-MRI was performed on two preclinical cancer models using a spoiled multiple gradient-echo acquisition, which enabled correction for transverse relaxation. Not accounting for R2* resulted in underestimation of the Tofts pharmacokinetic parameters, with Ktrans being the most affected and vp the least. Simulations showed that the R2* effect can be significant even at 3T in highly perfused regions but can be mitigated by decreasing TE and TR or increasing the flip angle.

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