When using linear least squares to estimate pharmacokinetic model parameters in dynamic contrast-enhanced MRI there is a risk of introducing bias due to noise correlations. By using a weighted total least squares (WTLS) method instead, these correlations are taking into account. The results of this study shows that the WTLS method is able to reduce the bias considerably compared to the linear least squares method for the two compartment exchange model, however, at the expense of increased computational time.
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