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Abstract #4387

Diffusion-weighted MRI of rectal cancer: baseline tumour perfusion fraction predicts chemoradiotherapy response and survival

Kine Mari Bakke1,2, Knut Håkon Hole3, Svein Dueland4, Krystyna Grøholt5, Kjersti Flatmark6,7,8, Anne Hansen Ree1,8, Therese Seierstad3, and Kathrine Røe Redalen1

1Department of Oncology, Akershus University Hospital, Lørenskog, Norway, 2Institute of physics, University of Oslo, Oslo, Norway, 3Department of Radiology and Nuclear Medicine, Oslo University Hospital, 4Department of Oncology, Oslo University Hospital, 5Department of Pathology, Oslo University Hospital, 6Department of Tumor Biology, Oslo University Hospital, 7Department of Gastroenterological Surgery, Oslo University Hospital, 8Institute of Clinical Medicine, University of Oslo

More accurate diagnostics for prediction of treatment responses in locally advanced rectal cancer is warranted. We employed a simplified approach to the intravoxel incoherent motion imaging method to estimate the tumour perfusion fraction from diffusion-weighted MRI. The perfusion fraction was predictive of the histologic tumour response after chemoradiotherapy (p = 0.02), and in combination with tumour volume this parameter was also predictive of five-year progression-free survival of the patients (p = 0.002). This simplified approach does not require substantial extra scan time in a routine diagnostic scanning, and may offer a clinically feasible approach to stratifying patients to individualised treatment.

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