Abstract #4389

Discriminatory ability of MRSI and DW-MRI in prostatic diseases in biopsy naïve men with PSA 4-10 ng/ml

Durgesh Kumar Dwivedi^1,2, Rajeev Kumar³, Alok Kumar Dwivedi⁴, Girdhar S. Bora³, Sanjay Thulkar⁵, Sanjay Sharma⁵, Siddhartha Datta Gupta⁶, and Naranamangalam R. Jagannathan¹

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India, ²Department of Radiodiagnosis, King George's Medical University, Lucknow, India, ³Department of Urology, All India Institute of Medical Sciences, New Delhi, Delhi, India, ⁴Division of Biostatistics and Epidemiology, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, Texas, TX, United States, ⁵Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, New Delhi, India, ⁶Department of Pathology, All India Institute of Medical Sciences, New Delhi, New Delhi, India

Multivariate approach of including different MR parameters offer a holistic view of entire data, which could provide better approach in differentiating various prostatic diseases. This approach may help in reducing the burden of unnecessary biopsy in men with PSA 4-10 ng/ml. we evaluated discriminatory ability of MRSI and DW-MRI in prostatic diseases in biopsy naïve men with PSA 4-10 ng/ml. The combined model (PSA + ADC + metabolite ratio) showed highest discriminatory ability in various prostatic diseases with AUC of 89% in men with clinically challenging group of PSA.

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