Meeting Banner
Abstract #4390

Diffusion Weighted Fast Spin Echo for tumor delineation in head-and-neck radiotherapy: a comparison with FDG-PET

Tim Schakel1, Boris Peltenburg1, Jan-Willem Dankbaar2, Carlos Cardenas3, Michalis Aristophanous3, Chris Terhaard1, Hans Hoogduin2, and Marielle Philippens1

1Department of Radiotherapy, UMC Utrecht, Utrecht, Netherlands, 2Department of Radiology, UMC Utrecht, Utrecht, Netherlands, 3Department of Radiation Physics, MD Anderson Cancer Center, TX, United States

DWI shows high contrast between tumor and surrounding tissue, which shows potential for target volume delineation in head-and-neck radiotherapy treatment planning. In this study we assess the performance of a diffusion weighted fast spin echo sequence (DW-SPLICE) for target delineation in terms of interobserver agreement and spatial concordance with PET. Fifteen patients underwent both PET and DW-SPLICE. PET was segmented using a Gaussian mixture model, DW-SPLICE was delineated by 3 observers. Target volume delineation using DWI is feasible in head-and-neck radiotherapy. Using an optimized DWI sequence, target volumes could be defined with good interobserver agreement and large similarity with PET.

This abstract and the presentation materials are available to members only; a login is required.

Join Here