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Abstract #4393

Longitudinal diffusion MRI for treatment assessment of sarcoma patients with pre-operative radiation therapy

Yingli Yang1, Minsong Cao1, Yu Gao2, Mitchell Kamrava1, Anusha Kalbasi1, Nzhde Agazaryan1, James Lamb1, Ke Sheng1, Daniel Low1, and Peng Hu2

1Radiation Oncology, UCLA, Los Angeles, CA, United States, 2Radiology, UCLA, Los Angeles, CA, United States

Diffusion weighted MRI (DWI) is promising for early prediction of tumor response to radiation therapy. We report our results of using longitudinal DWI approach performed on ViewRay system for predicting the response of sarcoma patient to pre-op RT. Six sarcoma patients were recruited in this study. Each patient subsequently underwent surgery. The tumor necrosis score was then used to compare to the ADC values to assess the predictive value of longitudinal DWI. Each patient successfully underwent 3–5 diffusion MRI scans. Based on the data from 6 patients, our longitudinal changes in tumor ADC matched well with pathology necrosis results.

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