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Abstract #4394

Integrated volumetric diffusion-weighted MR imaging and HPV genotyping in outcome prediction for stage IB-IV cervical cancer patients following chemoradiation therapy

Gigin Lin1, Chyong-Huey Lai1, and Yu-Chun Lin1

1Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taiwan

We evaluated the values of integration of pretreatment volumetric ADC analysis with human papillomavirus (HPV) genotyping in prediction of survival and recurrence for women with locally advanced cervical cancer in 82 women following concurrent chemoradiation therapy (CCRT). Independent poor prognostic indicators for OS and DFS by stepwise multivariate analysis, i.e., lower ADC10, advanced T or M stage and high-risk HPV status were composed to generate a novel outcome-predicting model, in which death was found in all the high-risk group patients whiles none of the low-risk group died or recurred during the follow up.

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