Meeting Banner
Abstract #4395

Longitudinal assessment of tumor volume and apparent diffusion coefficient in patients on active surveillance: a good way of monitoring disease progression?

Veronica A Morgan1, Christopher Parker2, and Nandita M deSouza1

1CRUK Imaging Centre, The Institute of Cancer Research, Surrey, United Kingdom, 2Academic Urology Unit, The Royal Marsden Hospital NHS Foundation Trust, Sutton, United Kingdom

Tumor growth on T2-W MRI in 151 men with low-risk prostate cancer managed by active surveillance was related to tumor apparent diffusion coefficient (ADC). Volume increases greater than the 95% upper Limits of Agreement of reproducibility (~60%, n=20) were seen in 52 (34.4%) men. ADC was more reproducible (~5% variability). Baseline ADC values did not differ between those with and without measurable growth (p=0.06) but change in ADC did (-6.8±12.3% for those with measurable growth vs. 0.23±10.1% for those without, p=0.0005). A 5.6% reduction in ADC with time indicated a measurable increase in tumor volume (specificity 77.0%, sensitivity 54.9%, AUC=0.67).

This abstract and the presentation materials are available to members only; a login is required.

Join Here