We present the clinical evaluation results of a novel approach for acquisition time reduction in 3D multispectral imaging near implants. Two musculoskeletal radiologists compared standard MAVRIC SL sequences to spectrally calibrated MAVRIC SL sequences for exams of instrumented hips, knees, and shoulders. Initial results demonstrated maintenance of diagnostic information in the hips when the calibration is utilized. Rotator cuff evaluation was still limited in the shoulder using the calibrated technique but evaluation of the other structures was nearly equivalent. Calibrated imaging of the knee showed reductions of SNR, which will inform future adjustment of targeted calibrated protocols in this joint.