Abstract #4465

Histology-Derived pseudo-ADC correlates with measured ADC and extranuclear space in a transgenic model of prostate cancer, identifying contribution of luminal space to measured ADC.

Matthew David Blackledge^1,2, Konstantinos Zormpas-Petridis¹, Andreas Heindl³, Siver A. Moestue⁴, Yinyin Yuan³, Dow Mu Koh^1,2, David J Collins^1,2, Yann Jamin¹, Tone F. Bathen⁴, Martin O Leach^1,2, and Deborah K. Hill⁴

¹Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom, ²MRI Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, ³Division of Molecular Pathology & Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom, ⁴Institute of Circulation and Medical Imaging, NTNU - Norwegian University of Science and Technology, Trondheim, Norway

In this preclinical study we investigate the utility of in-silico simulations of the pseudo-apparent diffusion coefficient (pADC) of water within extra-nuclear regions segmented on large field-of-view haematoxylin, eosin, and saffron (HES) slides from a transgenic mouse model of prostate cancer. We demonstrate that pADC is correlated within in-vivo measurements of the apparent diffusion coefficient (ADC) measured by diffusion-weighted magnetic resonance imaging and may thus be used as a surrogate for exploring the effect of tissue structure on measured ADC values. Furthermore, we demonstrate that ADC is correlated with fractional space occupied by lumen, derived from semi-automatic segmentation of HES slides.

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