Meeting Banner
Abstract #4465

Histology-Derived pseudo-ADC correlates with measured ADC and extranuclear space in a transgenic model of prostate cancer, identifying contribution of luminal space to measured ADC.

Matthew David Blackledge1,2, Konstantinos Zormpas-Petridis1, Andreas Heindl3, Siver A. Moestue4, Yinyin Yuan3, Dow Mu Koh1,2, David J Collins1,2, Yann Jamin1, Tone F. Bathen4, Martin O Leach1,2, and Deborah K. Hill4

1Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom, 2MRI Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, 3Division of Molecular Pathology & Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom, 4Institute of Circulation and Medical Imaging, NTNU - Norwegian University of Science and Technology, Trondheim, Norway

In this preclinical study we investigate the utility of in-silico simulations of the pseudo-apparent diffusion coefficient (pADC) of water within extra-nuclear regions segmented on large field-of-view haematoxylin, eosin, and saffron (HES) slides from a transgenic mouse model of prostate cancer. We demonstrate that pADC is correlated within in-vivo measurements of the apparent diffusion coefficient (ADC) measured by diffusion-weighted magnetic resonance imaging and may thus be used as a surrogate for exploring the effect of tissue structure on measured ADC values. Furthermore, we demonstrate that ADC is correlated with fractional space occupied by lumen, derived from semi-automatic segmentation of HES slides.

This abstract and the presentation materials are available to members only; a login is required.

Join Here