We report the use of semi-quantitative dynamic contrast enhanced (DCE)-MRI to identify differences in the growth and vascular environment seen within two murine hepatocellular carcinoma (HCC) models - cellular orthotopic injection (COI) (representing a traditional tumor model) or surgical orthotopic implantation (SOI) of tumor fragments (representing a patient-derived orthotopic xenograft model, or PDOX). Uptake curves of gadolinium contrast agent indicate differences in vasculature between the two models, highlighting important considerations to be made when trying to use PDOX methods to model HCC in the clinic.
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