Abstract #4467

Intrinsic susceptibility MRI predicts response to the vascular endothelial growth factor receptor inhibitor cediranib in the Th-MYCN model of neuroblastoma

Yann Jamin¹, Evon Poon², Neil P. Jerome¹, Alexander Koers², Laura S. Danielson², Dow-Mu Koh¹, Louis Chesler², and Simon P. Robinson¹

¹Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, London, United Kingdom, ²Division of Cancer Therapeutics and Division of Clinical Studies, The Institute of Cancer Research, London, London, United Kingdom

In this study we demonstrate that the transverse relaxation rate R₂* predicts response to the vascular endothelial growth factor receptor (VEGFR) inhibitor cediranib in the Th-MYCN genetically-engineered murine model of neuroblastoma, a childhood cancer of the developing nervous system.

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