Abstract #4471

Probing tumor metabolism using dynamic lactate chemical exchange saturation transfer MRI

Puneet Bagga¹, Mohammad Haris², Pranav Jain¹, Alekya Bheemreddy¹, Francesco Marincola², Hari Hariharan¹, and Ravinder Reddy¹

¹Department of Rediology, University of Pennsylvania, Philadelphia, PA, United States, ²Research Branch, Sidra Medical and Research Center, Doha, Qatar

Lactate CEST (LATEST) MRI method has been shown to be applicable in detecting and imaging changes in the lactate level in human subjects post heavy exercise and to measure the lactate in a mouse model of lymphoma. In this study, LATEST was implemented to probe the lactate dehydrogenase (LDH) activity in vivo in a rat glioma model. Following the administration of pyruvate, the LATEST contrast is elevated in the tumor region while it is unaltered in the unaffected region.

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