Meeting Banner
Abstract #4470

A Genetically Engineered Mouse Model Recapitulates Radiological Features of Human Adamantinomatous Craniopharyngioma

Jessica KR Boult1, Ciaran Hutchinson2, John R Apps3, Gabriela Carreno3, Laura S Danielson4, Laura M Smith4, Alex K Virasami2, Alexander Koers4, Louis Chesler4, Owen J Arthurs2, Juan Pedro Martinez-Barbera3, and Simon P Robinson1

1Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom, 2Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 3Birth Defects Research Centre, Institute of Child Health, University College London, London, United Kingdom, 4Division of Clinical Sciences, The Institute of Cancer Research, London, United Kingdom

Tumours in Hesx1Cre/+;Ctnnb1lox(ex3)/+ mice resemble human adamantinomatous craniopharyngioma (ACP) molecularly and histologically. MRI and ex vivo micro-CT were used to assess the radiology of this model for the first time. Early enlargement and heterogeneity of Hesx1Cre/+;Ctnnb1lox(ex3)/+ pituitaries was evident; enlargement of a solid tumour, and development of cysts and haemorrhage subsequently occurred. Solid components showed heterogeneous T1-weighted signal enhancement following Gd-DTPA administration, and in some animals cysts were hyperintense on FLAIR and T1-weighted images, both emulating clinical observations. Cyst calcification was not observed by micro-CT but we show that Hesx1Cre/+;Ctnnb1lox(ex3)/+ tumours faithfully recapitulate the MRI radiology of the human disease.

This abstract and the presentation materials are available to members only; a login is required.

Join Here