Abstract #4475

Intratumoral vessel evaluation using magnetic resonance micro-angiography with a vascular pool Gd-DOTA-dendron liposomal contrast agent

Nobuhiro Nitta^1,2, Daisuke Kokuryo³, Sayaka Shibata¹, Kenji Kono⁴, Akihiro Tomita⁵, Jeff Kershaw¹, Ichio Aoki¹, and Masafumi Harada²

¹Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological, Chiba, Japan, ²Radiology and Radiation Oncology, Graduate School of Medicine, Tokushima University, Tokushima, Japan, ³Graduate School of System informatics, Kobe University, Hyogo, Japan, ⁴Graduate School of Engineering, Osaka Prefecture University, Osaka, Japan, ⁵Graduate School of Medicine, Nagoya University, Aichi, Japan

Evaluation of the intratumor environment, such as cell distribution and vessel structure, are important for understanding the characteristics of tumors. In particular, the vessel structure and its permeability is critical for the malignant potential of the tumor and drug-targeting. The purpose of this work was to non-invasively visualize intratumoral vessels using MR micro-angiography (MRmA) and a liposomal contrast agent having long blood half-life. In addition, we tried to identify differences in the vascular structures for Colon26 and SU-DHL6 cells. The proposed method visualized the intratumoral vessels clearly and revealed differences in the structure depending on the cell type.

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