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Abstract #4475

Intratumoral vessel evaluation using magnetic resonance micro-angiography with a vascular pool Gd-DOTA-dendron liposomal contrast agent

Nobuhiro Nitta1,2, Daisuke Kokuryo3, Sayaka Shibata1, Kenji Kono4, Akihiro Tomita5, Jeff Kershaw1, Ichio Aoki1, and Masafumi Harada2

1Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological, Chiba, Japan, 2Radiology and Radiation Oncology, Graduate School of Medicine, Tokushima University, Tokushima, Japan, 3Graduate School of System informatics, Kobe University, Hyogo, Japan, 4Graduate School of Engineering, Osaka Prefecture University, Osaka, Japan, 5Graduate School of Medicine, Nagoya University, Aichi, Japan

Evaluation of the intratumor environment, such as cell distribution and vessel structure, are important for understanding the characteristics of tumors. In particular, the vessel structure and its permeability is critical for the malignant potential of the tumor and drug-targeting. The purpose of this work was to non-invasively visualize intratumoral vessels using MR micro-angiography (MRmA) and a liposomal contrast agent having long blood half-life. In addition, we tried to identify differences in the vascular structures for Colon26 and SU-DHL6 cells. The proposed method visualized the intratumoral vessels clearly and revealed differences in the structure depending on the cell type.

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