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Abstract #4476

MR image analysis to identify habitats through comparison with histology and immunohistochemistry in breast cancer

Bruna V. Jardim-Perassi1,2, William Dominguez-Viqueira2, Mikalai Budzevich2, Epifanio Ruiz2, Suning Huang2, Jan Poleszczuk3, Alex S Lopez4, Debora APC Zuccari1, Gary Martinez2, and Robert Gillies2

1Molecular Biology, Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose do Rio Preto, Brazil, 2Cancer Imaging and Metabolism, Moffitt Cancer Center, Tampa, FL, United States, 3Nalecz Institute of Biocybernetics and Biomedical Engineering, Poland, 4Oncologic Sciences, Moffitt Cancer Center, Tampa, FL, United States

Breast cancer shows significant heterogeneity at both inter- and intratumoral levels. In this study, a distribution clustering of multiple MRI pulse sequences was used in combination with a 3D printed approach, and showed a qualitatively comparable pattern of intratumoral heterogeneity (habitats) in MRI and histological images. This approach could potentially be used as a non-invasive imaging method for the monitoring of the intratumoral heterogeneity following the therapy in breast cancer.

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