Abstract #4476

MR image analysis to identify habitats through comparison with histology and immunohistochemistry in breast cancer

Bruna V. Jardim-Perassi^1,2, William Dominguez-Viqueira², Mikalai Budzevich², Epifanio Ruiz², Suning Huang², Jan Poleszczuk³, Alex S Lopez⁴, Debora APC Zuccari¹, Gary Martinez², and Robert Gillies²

¹Molecular Biology, Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose do Rio Preto, Brazil, ²Cancer Imaging and Metabolism, Moffitt Cancer Center, Tampa, FL, United States, ³Nalecz Institute of Biocybernetics and Biomedical Engineering, Poland, ⁴Oncologic Sciences, Moffitt Cancer Center, Tampa, FL, United States

Breast cancer shows significant heterogeneity at both inter- and intratumoral levels. In this study, a distribution clustering of multiple MRI pulse sequences was used in combination with a 3D printed approach, and showed a qualitatively comparable pattern of intratumoral heterogeneity (habitats) in MRI and histological images. This approach could potentially be used as a non-invasive imaging method for the monitoring of the intratumoral heterogeneity following the therapy in breast cancer.

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