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Abstract #4477

Electric field and current density mapping during reversible Electroporation

Munish Chauhan1, Neeta Ashok Kumar1, Vikram D Kodibagkar1, and Rosalind J Sadleir1

1School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States

Electroporation is popular in cancer therapy and gene or drug delivery. Magnetic Resonance Electrical Impedance Tomography (MREIT) was used to monitor the applied electric field and current density during electroporation. Electroporation fields were applied by novel low-susceptibility carbon fiber electrodes in a bovine liver tissue sample. Projected current density (JP) and Electric field (E) were computed from MR data collected under electroporation fields. Susceptibility artifacts around the pair of carbon fiber electrodes were greatly reduced. In this study, we demonstrated the feasibility of MREIT technique to monitor the current density and electric field distribution during ex-vivo tissue electroporation.

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