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Abstract #4478

Diffusion Kurtosis Imaging Evaluating Epithelial–mesenchymal Transition in Colorectal Carcinoma Xenografts Model: Initial Experience

Huanhuan Liu1, Caiyuan Zhang2, Jinning Li2, Weibo Chen3, and Dengbin Wang2

1Department of Radiology, Xinhua hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China, 2Department of Radiology, Xinhua hospital, Shanghai Jiaotong University School of Medicine, People's Republic of China, 3Philips Healthcare, People's Republic of China

Colorectal cancer (CRC) is one of the most common malignant tumors in gastrointestinal tract. Tumor recurrence and metastasis are still a major cause of death in rectal cancer patients. Epithelial-mesenchymal transition (EMT) is reported a critical process providing tumor cells with the ability to migrate and metastasize to distant sites, leading to a poor prognosis in CRC. The diffusion kurtosis imaging (DKI) could quantify non-Gaussian behavior of water diffusion and provide more precise information of tissue characteristics. Our study demonstrated that DKI could be used to identify EMT in CRC xenograft models.

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