Abstract #4479

Telomerase expression enhances pentose phosphate pathway flux resulting in an MR-detectable increase in reduced glutathione levels in mutant IDH1 glioma cells

Pavithra Viswanath¹, Russell O Pieper², and Sabrina M Ronen¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

Telomerase is the enzyme responsible for maintenance of telomeres, which are special capped structures that protect chromosomal ends from degradation. Telomerase activation and metabolic reprogramming have both emerged as hallmarks of cancer. Here, we investigated the link between telomerase and metabolism in mutant isocitrate dehydrogenase 1 (IDH1) glioma cells with the goal of identifying MR-detectable biomarkers of telomerase expression. Using ¹³C- and ¹H- MRS, we show that telomerase expression is associated with elevated flux through the pentose phosphate pathway resulting in increased levels of reduced glutathione (GSH). Thus, GSH is a potential biomarker of telomerase expression in mutant IDH1 gliomas.

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