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Abstract #4481

Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer

Devkumar Mustafi1, Abby Leinroth1, Xiaobing Fan1, Erica Markiewicz1, Marta Zamora1, Jeffrey Mueller2, Suzanne D Conzen3, and Gregory S Karczmar1

1Radiology, The University of Chicago, Chicago, IL, United States, 2Pathology, The University of Chicago, Chicago, IL, United States, 3Medicine, the Section of Hematology and Oncology, The University of Chicago, IL, United States

Breast cancer is a major cause of morbidity and mortality in Western women. Tumor neo-angiogenesis may be an MRI-detectable prognostic marker for cancer progression. Clinical practice uses DCE-MRI to detect cancers based on increased blood flow and capillary permeability. However, DCE-MRI requires repeated injections of contrast media; therefore we used time-of-flight MR angiography to measure the number and size of arteries feeding mammary glands with and without cancer, and demonstrated that blood vessels in and near mammary glands grew significantly as invasive cancers developed.

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