Abstract #4482

In vivo hyperpolarized [1-13C]pyruvate and [18F]-FDG PET/CT studies of prostate cancer metastasis xenografts in mice

Frits H.A. van Heijster¹, Sandra Heskamp¹, Andor A. Veltien¹, Tom H. Peeters¹, Tom W.J. Scheenen¹, Otto C. Boerman¹, and Arend Heerschap¹

¹Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands

Understanding the underlying mechanisms of aggressiveness is important for better staging and treatment of prostate cancer. In this study two murine xenograft models of early and late stage prostate cancer were investigated. [1-¹³C]pyruvate was hyperpolarized by Dynamic Nuclear Polarization (DNP) and pyruvate metabolism is followed by ¹³C-MR. This is combined with [¹⁸F]FDG-PET/CT to study glucose metabolism. We found differences in pyruvate conversion and glucose uptake in vivo in the murine models.

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