Abstract #4483

Multi-agent dynamic contrast enhanced MRI to assess vascular changes induced by prolonged VEGFR2 inhibition in oesophageal cancer

Remy Klaassen^1,2, Anne Steins^1,2, Matthias C Schabel^3,4, Igor Jacobs⁵, Maarten F Bijlsma², Aart J Nederveen⁶, Gustav J Strijkers⁷, and Hanneke WM van Laarhoven¹

¹Medical Oncology, Academic Medical Center, Amsterdam, Netherlands, ²LEXOR, Academic Medical Center, Amsterdam, Netherlands, ³Advanced Imaging Research Center, Oregon Health & Science University, Portland, OH, United States, ⁴Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, ⁵Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ⁶Radiology, Academic Medical Center, Amsterdam, Netherlands, ⁷Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

The effective vascular changes induced by prolonged VEGFR2 inhibition and the resulting changes in vascular function are difficult to monitor in vivo and therefore largely unexplored. In this study we show a multi-agent DCE-MRI approach, using 3 different-sized contrast agents, to quantify effects on vascularization induced by prolonged VEGFR2 inhibition in an oesophageal cancer mouse model. Effects on vascularization were predominantly observed in parameters dependent on the larger-sized contrast agents, where no effects where found for the traditional low-molecular weight contrast agent.

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