Abstract #4488

Validation of an efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse.

Veerle Kersemans¹, John S Beech¹, Stuart Gilchrist¹, Paul Kinchesh¹, Philip D Allen¹, James Thompson¹, Ana L Gomes¹, Zenobia D'Costa¹, Luke Bird¹, Iain DC Tullis¹, Robert G Newman¹, Abul Azad¹, Ruth J Muschel¹, Borivoj Vojnovic¹, Mark A Hill¹, Emmanouil Fokas¹, and Sean C Smart¹

¹CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom

The aim was to develop and validate a robust and accurate method of MR-IGRT delivery to abdominal targets in the mouse that takes advantage of the strengths of each of its components: MRI for soft tissue contrast and target identification, CBCT for accurate dose calculation and IGRT for accurate, collimated X-ray beam delivery. A multimodality cradle was developed and evaluated to enable transfer of the mouse between MR and the IGRT platform. Additionally, each step of the MG-IGRT process was validated, both in vitro using BANG gel dosimeters and in vivo by targeting the adrenal glands in mice.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.