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Abstract #4488

Validation of an efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse.

Veerle Kersemans1, John S Beech1, Stuart Gilchrist1, Paul Kinchesh1, Philip D Allen1, James Thompson1, Ana L Gomes1, Zenobia D'Costa1, Luke Bird1, Iain DC Tullis1, Robert G Newman1, Abul Azad1, Ruth J Muschel1, Borivoj Vojnovic1, Mark A Hill1, Emmanouil Fokas1, and Sean C Smart1

1CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom

The aim was to develop and validate a robust and accurate method of MR-IGRT delivery to abdominal targets in the mouse that takes advantage of the strengths of each of its components: MRI for soft tissue contrast and target identification, CBCT for accurate dose calculation and IGRT for accurate, collimated X-ray beam delivery. A multimodality cradle was developed and evaluated to enable transfer of the mouse between MR and the IGRT platform. Additionally, each step of the MG-IGRT process was validated, both in vitro using BANG gel dosimeters and in vivo by targeting the adrenal glands in mice.

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