Abstract #4487

Transport across the blood-brain-barrier may be limiting for hyperpolarized [1-13C]pyruvate neuro-oncology studies

Jack Julian James Jenkins Miller^1,2,3, James Larkin⁴, Katherine R Fisher¹, Vicky Ball¹, Kevin J Ray⁴, Sebastien Serres⁵, Damian John Tyler^1,2, Angus Zoen Lau^1,6, and Nicola Ruth Sibson⁴

¹Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, ²Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, ³Department of Physics, University of Oxford, Oxford, United Kingdom, ⁴Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom, ⁵School of Life Sciences, University of Nottingham, Nottingham, United Kingdom, ⁶Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

Hyperpolarized pyruvate has previously been used to probe primary brain cancer. Through imaging the delivery and metabolism of both hyperpolarized [1-¹³C]pyruvate and ethyl-[1-¹³C]pyruvate in a rodent model of cancer metastasis to the brain, we show that the transport of [1-¹³C]pyruvate across the blood brain barrier may be limiting until it is compromised by metastatic cell infiltration.

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