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Abstract #4487

Transport across the blood-brain-barrier may be limiting for hyperpolarized [1-13C]pyruvate neuro-oncology studies

Jack Julian James Jenkins Miller1,2,3, James Larkin4, Katherine R Fisher1, Vicky Ball1, Kevin J Ray4, Sebastien Serres5, Damian John Tyler1,2, Angus Zoen Lau1,6, and Nicola Ruth Sibson4

1Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, 2Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 3Department of Physics, University of Oxford, Oxford, United Kingdom, 4Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom, 5School of Life Sciences, University of Nottingham, Nottingham, United Kingdom, 6Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

Hyperpolarized pyruvate has previously been used to probe primary brain cancer. Through imaging the delivery and metabolism of both hyperpolarized [1-13C]pyruvate and ethyl-[1-13C]pyruvate in a rodent model of cancer metastasis to the brain, we show that the transport of [1-13C]pyruvate across the blood brain barrier may be limiting until it is compromised by metastatic cell infiltration.

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