Abstract #4486

Multiparametric MRI for optimal prostate cancer detection in TRAMP mice

Jana Kim¹, Eugene Kim¹, Deborah K. Hill¹, Dan E. Meyer², Karina Langseth³, Frits A. Thorsen⁴, Tone F. Bathen¹, and Siver A. Moestue¹

¹Department of Circulation and Medical Imaging, NTNU - Norwegian University of Science and Technology, Trondheim, Norway, ²Diagnostics, Imaging and Biomedical Technologies, GE Global Research Center, Niskayuna, NY, United States, ³GE Healthcare AS, Oslo, Norway, ⁴Department of Biomedicine, University of Bergen, Bergen, Norway

Multiparametric MRI is the standard for the detection and characterization of prostate cancer. In this study we compared the diagnostic value of clinically used DW-MRI and DCE-MRI in a transgenic mouse model of prostate cancer (TRAMP). Additionally, we investigated the potential utility of SSC-MRI using a USPIOs contrast agent for prostate cancer detection. The results of this study confirm the utility of DW-MRI and the potential value of DCE-MRI in early-stage detection and monitoring of prostate cancer. SSC-MRI appears to be less useful for this task in the TRAMP model, but further analysis is required to draw a clear conclusion.

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