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Abstract #4485

Imaging Collagenase-Induced Changes in the Mechanical Phenotype of Orthotopic BT474 Breast Cancer Xenografts Using Magnetic Resonance Elastography

Jin Li1, Jessica K.R. Boult1, Craig Cummings1, Jeffrey C. Bamber1, Ralph Sinkus2, Yann Jamin1, and Simon P. Robinson1

1Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, United Kingdom, 2Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, United Kingdom

We tested the hypothesis that MRE can inform on collagenase-induced matrix degradation in orthotopic BT474 breast carcinoma xenografts in vivo. An acute reduction in the absolute value of the complex shear modulus |G*| was detected in tumour just 5 hours after collagenase administration, mostly likely a consequence of both collagen degradation and reduction of interstitial fluid pressure. The study highlights the utility of MRE-derived quantitation of tumour viscoelasticity for monitoring the response of stromal rich tumours to modification of the extracellular matrix.

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