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Abstract #4494

On Molecular Aspects of Ktrans and Angiogenesis: Cerebral Gliomas

Charles S. Springer, Jr.1, Xin Li1, Seymur Gahramanov2, Martin M. Pike1, William D. Rooney1, and Edward A. Neuwelt3

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Neurosurgery, University of New Mexico, Albuquerque, NM, United States, 3Blood Brain Barrier Program, Oregon Health & Science University, Portland, OR, United States

It is often thought that tumor Ktrans value differences correspond to changes in capillary contrast agent (CA) permeability. We show this is not the case for implanted glioma in rat brain. Over an almost eight-fold Ktrans change, the tumor CA extravasation rate constant kpe remains relatively fixed, as if regulated, but at a value greater than normal. The Ktrans changes reflect cerebral blood volume fraction changes.

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